It is 1851, and a lust for gold has swept the American frontier.
Two brothers - the notorious Eli and Charlie Sisters - are on the road to California, following the trail of an elusive prospector, Hermann Kermit Warm. On this odyssey Eli and his brother cross paths with a remarkable cast of characters - losers, cheaters, and ne'er-do-wells from all stripes of life - and Eli begins to question what he does for a living, and whom he does it for.